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Shock. 2017 Dec;48(6):638-643. doi: 10.1097/SHK.0000000000000903.

Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns.

Author information

1
*Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands †Academic Pediatric Center Suriname, Paramaribo, Suriname ‡Scientific Research Center Suriname, Academic Hospital Paramaribo, Paramaribo, Suriname §Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands ||Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands ¶Department of Pediatrics, Diakonessen Hospital, Paramaribo, Suriname #Department of Pediatrics, Tergooi Hospitals, Blaricum, The Netherlands.

Abstract

PURPOSE:

Vascular inflammation and leakage in sepsis is mediated by Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) and their phosphorylation of the endothelial Tie-2 receptor. This study investigates levels of Ang-1 and Ang-2 in newborns to gain insight in the vascular pathophysiology of early onset sepsis (EOS) within 72 h after birth.

METHODS:

A prospective cohort study was performed among 71 Surinamese newborns treated with antibiotics for suspected EOS and 20 control newborns. Newborns with suspected EOS were divided in two groups: blood culture negative and positive EOS. Ang-1 and Ang-2 levels were measured in serum obtained at the start of antibiotic treatment and at re-evaluation after 48 to 72 h.

RESULTS:

In this cohort 8.5% of newborns had a positive blood culture. At the start of antibiotic treatment Ang-1 serum levels were lower (P < 0.01), and Ang-2 and Ang-2/Ang-1 serum protein ratios were higher (P < 0.01 and P < 0.01, respectively) in newborns with blood culture positive EOS than in controls. These levels were not dependent on timing of first blood draw after birth. After 48 to 72 h levels of Ang-1 further decreased in blood culture positive EOS, while in the other groups no change was observed.

CONCLUSIONS:

Our findings support the hypothesis that a disbalance in the Angiopoietins plays a role in the vascular pathophysiology of EOS.

PMID:
28538018
PMCID:
PMC5647105
DOI:
10.1097/SHK.0000000000000903
[Indexed for MEDLINE]
Free PMC Article

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