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Nutr Clin Pract. 2017 Jun;32(3):337-345. doi: 10.1177/0884533616674492. Epub 2016 Oct 21.

Role of Vitamin D in Inflammatory Bowel Disease.

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1 Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
2 Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.


Vitamin D is a secosteroid hormone that possesses immunomodulatory properties and has been demonstrated to potentially influence inflammatory bowel disease (IBD) pathogenesis and activity. Epidemiologic data have associated vitamin D deficiency with an increased risk of IBD, hospitalizations, surgery, and loss of response to biologic therapy. Conversely, IBD itself can lead to vitamin D deficiency. This bidirectional relationship between vitamin D and IBD suggests the need for monitoring and repletion of vitamin D, as needed, in the IBD patient. This review discusses the role of vitamin D in IBD and provides practical guidance on vitamin D repletion.


Crohn’s disease; cholecalciferol; ergocalciferol; inflammatory bowel diseases; ulcerative colitis; vitamin D; vitamin D deficiency

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