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AIDS Behav. 2018 Jan;22(1):265-275. doi: 10.1007/s10461-017-1795-5.

Does Diagnosis Make a Difference? Estimating the Impact of an HIV Medication Adherence Intervention for Persons with Serious Mental Illness.

Author information

1
Department of Psychiatry and Behavioral Science, Lewis Katz School of Medicine, Temple University, Episcopal Campus, 100 E Lehigh Ave MAB 305, Philadelphia, PA, 19125, USA. natasha.dalseth@tuhs.temple.edu.
2
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
3
Campus Edge Advisors LLC, Branford, CT, USA.

Abstract

The heightened risk of persons with serious mental illness to contract and transmit human immunodeficiency virus (HIV) is a public health problem. Here we evaluate the interaction between psychiatric diagnosis and response to a community based-intervention targeted at treatment adherence in 236 HIV+ persons with co-occurring mental illness. To examine differential effectiveness of the intervention for categories of patient diagnosis, we reanalyzed the data after stratifying participants into two diagnostic groups: (1) participants with depressive disorders without psychosis and (2) participants with a psychotic or bipolar disorder. Outcomes included viral load and mental health quality of life (SF-12 Mental Health). We found that HIV+ persons with non-psychotic depressive disorders demonstrated a larger decrease in HIV viral load and more improvement in measures of mental health quality of life when compared to HIV+ persons with psychotic and bipolar disorders. We suggest that successful adherence interventions should be informed by psychiatric symptomatology.

TRIAL REGISTRATION:

clinicaltrials.gov 29 identifier NCT00264823.

KEYWORDS:

HIV; PATH+; Psychiatric diagnosis; Root cause analysis; Treatment adherence

PMID:
28536741
PMCID:
PMC6281165
DOI:
10.1007/s10461-017-1795-5
[Indexed for MEDLINE]
Free PMC Article

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