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Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt C):273-278. doi: 10.1016/j.pnpbp.2017.05.008. Epub 2017 May 20.

Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy.

Author information

1
Department of Psychiatry, Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; Department of Psychological Medicine, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK; College of Medicine, Brain Disease Research Center (BDRC), China Medical University, Taichung, Taiwan.
2
Department of Psychiatry, Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; College of Medicine, Brain Disease Research Center (BDRC), China Medical University, Taichung, Taiwan.
3
Department of Psychiatry, Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
4
Department of Obstetrics, China Medical University Hospital, Taichung, Taiwan; College of Medicine, Brain Disease Research Center (BDRC), China Medical University, Taichung, Taiwan.
5
Department of Obstetrics, China Medical University Hospital, Taichung, Taiwan.
6
College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.
7
College of Public Health and Nutrition, Taipei Medical University, Taiwan.
8
Medical University of Łódź, Łódź, Poland.
9
Department of Psychiatry, Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; Department of Psychological Medicine, Institute of Psychiatry Psychology and Neuroscience, King's College London, UK; College of Medicine, Brain Disease Research Center (BDRC), China Medical University, Taichung, Taiwan. Electronic address: cobolsu@gmail.com.

Abstract

INTRODUCTION:

Prenatal depression (PND) is a common psychiatric disorder in pregnant women and leads to psychosocial dysfunction, high suicidal rate, and adverse childcare. Patients with PND have omega-3 polyunsaturated fatty acid (omega-3 or n-3 PUFAs) deficits, which might link to chronic low-grade inflammatory process and the pathophysiological mechanisms of depression. In this case-control study, we examined the levels of PUFAs and inflammatory cytokines in PND.

METHOD:

Blood samples were obtained and analyzed from 16 healthy controls and 17 depressed cases (PND group) diagnosed with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Independent sample t-test and correlation analysis were performed with Statistical Package for the Social Sciences (SPSS) logistics correlation analysis.

RESULTS:

PND group had significantly lower levels of total n-3 (p=0.026), docosahexaenoic acid (DHA) (p=0.020) and eicosapentaenoic (EPA) (p=0.019) but a higher omega-6 (n-6)/n-3 PUFAs ratio (p=0.007) and tumor necrosis factor alpha (TNF-α) (p=0.016) level. Moreover, the duration of current PND episodes were also significantly correlated with DHA, EPA, n-3 PUFAs, n-6/n-3 ratio and TNF-α. In terms of PUFAs and cytokine levels, only DHA was inversely correlated with TNF-α.

CONCLUSION:

PND is significantly associated with lower DHA, EPA, and total n-3 PUFAs levels and an increased n-6/n-3 PUFAs ratio, while the duration of PND is associated with lower levels of n-3 PUFAs, including DHA and EPA. The correlation of PUFAs levels with depression and TNF-α level grant further investigation into the inflammatory process underlying PND, mediated by PUFAs.

KEYWORDS:

Inflammation; Major depressive disorder; Perinatal depression (PND); Polyunsaturated fatty acids (PUFAs)

PMID:
28536068
DOI:
10.1016/j.pnpbp.2017.05.008
[Indexed for MEDLINE]

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