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Cell Physiol Biochem. 2017;42(1):306-318. doi: 10.1159/000477386. Epub 2017 May 25.

Resistant Starch Regulates Gut Microbiota: Structure, Biochemistry and Cell Signalling.

Yang X1,2, Darko KO1, Huang Y1,2, He C1,2, Yang H2, He S2, Li J2, Li J3, Hocher B3,4, Yin Y2,5.

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Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, China.
Animal Nutrition and Human Health Laboratory, College of Life Sciences, Normal University, Changsha, China.
Department of Basic Medicine, School of Medicine, Hunan Normal University, Changsha, China.
Institute of Nutritional Sciences, University of Potsdam, Potsdam, Germany.
Chinese Academy of Science, Institute of Subtropical Agriculture, Research Center for Healthy Breeding of Livestock and Poultry, Hunan Engineering and Research Center of Animal and Poultry Science and Key Laboratory for Agroecological Processes in Subtropical Region, Scientific Observation and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, China.


Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota.


Gut microbiota; Nutrition; Resistant starch

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