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Dev Cell. 2017 May 22;41(4):337-348. doi: 10.1016/j.devcel.2017.02.018.

Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.

Author information

1
Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: miriam.osterfield@utsouthwestern.edu.
2
Molecular and Cellular Biology Program and Department of Genome Sciences, University of Washington, Seattle, WA 98195-5065, USA.
3
Department of Chemical and Biological Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

Abstract

Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify unique cell types that construct epithelial tubes for specialized eggshell structures, has provided a tractable system to ask these questions. Work there has elucidated connections between scales of development, including across evolutionary scales, and fostered the development of quantitative modeling tools. These tools and general principles can be applied to the understanding of other developmental processes across organisms.

KEYWORDS:

Drosophila; computational modeling; dorsal appendage; eggshell; epithelia; evolution; follicular epithelium; morphogenesis; oogenesis; patterning

PMID:
28535370
PMCID:
PMC5443119
DOI:
10.1016/j.devcel.2017.02.018
[Indexed for MEDLINE]
Free PMC Article

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