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Nat Commun. 2017 May 23;8:15458. doi: 10.1038/ncomms15458.

Two forms of death in ageing Caenorhabditis elegans.

Author information

1
Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
2
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
3
Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
4
Department of Genetics, Washington University in St Louis, St. Louis, Missouri 63110, USA.
5
Max Planck Institute for Biology of Ageing, Köln D-50931, Germany.

Abstract

Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting pathologies in Caenorhabditis elegans with a necropsy analysis of worms that have died of old age. Our results imply the presence of multiple causes of death. Specifically, we identify two classes of corpse: early deaths with a swollen pharynx (which we call 'P deaths'), and later deaths with an atrophied pharynx (termed 'p deaths'). The effects of interventions on lifespan can be broken down into changes in the frequency and/or timing of either form of death. For example, glp-1 mutation only delays p death, while eat-2 mutation reduces P death. Combining pathology and mortality analysis allows mortality profiles to be deconvolved, providing biological meaning to complex survival and mortality profiles.

PMID:
28534519
PMCID:
PMC5457527
DOI:
10.1038/ncomms15458
[Indexed for MEDLINE]
Free PMC Article

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