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Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00385-17. doi: 10.1128/AAC.00385-17. Print 2017 Aug.

Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates.

Author information

1
Clinical Microbiology Laboratory, Department of Nosocomial Infection Control, Children's Hospital of Fudan University, Shanghai, China.
2
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
3
Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
4
Department of Laboratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
5
Clinical Microbiology Laboratory, Department of Nosocomial Infection Control, Children's Hospital of Fudan University, Shanghai, China chuanqing523@163.com hufupin@163.com.
6
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China chuanqing523@163.com hufupin@163.com.

Abstract

Five OXA-232 carbapenemase-producing Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15 (ST15), were isolated from neonates and coproduced blaCTX-M-15 and blaSHV-1 genes. All isolates were resistant to ertapenem (MICs of >32 μg/ml) and meropenem (MICs of 4 to 8 μg/ml) and susceptible or intermediate to imipenem (MICs of 1 to 2 μg/ml). The blaOXA-232 gene was located on a ColE-type transformable plasmid of 6,141 bp. To the best of our knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.

KEYWORDS:

Klebsiella pneumoniae; OXA-232; ST15; clonal dissemination; neonates

PMID:
28533245
PMCID:
PMC5527636
DOI:
10.1128/AAC.00385-17
[Indexed for MEDLINE]
Free PMC Article

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