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Biosci Biotechnol Biochem. 2017 Aug;81(8):1557-1560. doi: 10.1080/09168451.2017.1326087. Epub 2017 May 22.

Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases.

Author information

1
a Laboratory of Molecular Biology, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
2
b Laboratory of Bioindustrial Genomics, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.

Abstract

Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control.

KEYWORDS:

H2A.Z; SUMO-targeted ubiquitin ligases; chromatin; histone

PMID:
28532323
DOI:
10.1080/09168451.2017.1326087
[Indexed for MEDLINE]

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