Format

Send to

Choose Destination
Mar Drugs. 2017 May 20;15(5). pii: E145. doi: 10.3390/md15050145.

The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.

Author information

1
Department of Biology, University of Utah, Salt Lake City 84112, UT, USA. sam.robinson@utah.edu.
2
Eccles Institute of Human Genetics, University of Utah, Salt Lake City 84112, UT, USA. liqing850104@gmail.com.
3
School of Life Sciences and Technology, Institute of Protein Research, Tongji University, Shanghai 200092, China. aplv@tongji.edu.cn.
4
Department of Biology, University of Utah, Salt Lake City 84112, UT, USA. pradip.bandyopadhyay@gmail.com.
5
Eccles Institute of Human Genetics, University of Utah, Salt Lake City 84112, UT, USA. myandell@genetics.utah.edu.
6
USTAR Center for Genetic Discovery, University of Utah, Salt Lake City 84112, UT, USA. myandell@genetics.utah.edu.
7
Department of Biology, University of Utah, Salt Lake City 84112, UT, USA. olivera@biology.utah.edu.
8
Department of Biology, University of Utah, Salt Lake City 84112, UT, USA. helena.safavi@utah.edu.

Abstract

The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world. Today, cone snails have attracted attention for their remarkable venom components. Many conotoxins are proving valuable as research tools, drug leads, and drugs. In this article, we present the venom gland transcriptome of C. gloriamaris, revealing this species' conotoxin repertoire. More than 100 conotoxin sequences were identified, representing a valuable resource for future drug discovery efforts.

KEYWORDS:

Conus; Conus gloriamaris; cone snail; conotoxin; venom

PMID:
28531118
PMCID:
PMC5450551
DOI:
10.3390/md15050145
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center