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Nat Neurosci. 2017 Jul;20(7):960-968. doi: 10.1038/nn.4566. Epub 2017 May 22.

Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex.

Author information

1
Neural Circuits Laboratory, Friedrich Miescher Institute, Basel, Switzerland.
2
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
3
Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
4
The Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary.
5
Department of Ophthalmology, University of Basel, Basel, Switzerland.

Abstract

How neuronal computations in the sensory periphery contribute to computations in the cortex is not well understood. We examined this question in the context of visual-motion processing in the retina and primary visual cortex (V1) of mice. We disrupted retinal direction selectivity, either exclusively along the horizontal axis using FRMD7 mutants or along all directions by ablating starburst amacrine cells, and monitored neuronal activity in layer 2/3 of V1 during stimulation with visual motion. In control mice, we found an over-representation of cortical cells preferring posterior visual motion, the dominant motion direction an animal experiences when it moves forward. In mice with disrupted retinal direction selectivity, the over-representation of posterior-motion-preferring cortical cells disappeared, and their responses at higher stimulus speeds were reduced. This work reveals the existence of two functionally distinct, sensory-periphery-dependent and -independent computations of visual motion in the cortex.

PMID:
28530661
PMCID:
PMC5490790
DOI:
10.1038/nn.4566
[Indexed for MEDLINE]
Free PMC Article

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