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J Bone Jt Infect. 2017 Jan 1;2(1):29-37. doi: 10.7150/jbji.16067. eCollection 2017.

Therapeutic Use of Antibiotic-loaded Bone Cement in the Treatment of Hip and Knee Joint Infections.

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Zentrum für Orthopädie und Unfallchirurgie, Klinikum Saarbrücken, Saarbrücken, Germany.


The use of antibiotic-loaded cement spacers is an established method in the management of periprosthetic hip and knee joint infections. Despite inconsistencies among published studies, data shows that infection control rates exceed 90% with two-stage exchange arthroplasty. The present work reviews the current literature about antibiotic-loaded cement spacers and concentrates on the indications for spacer implantation, spacer production details, antibiotic impregnation, pharmacokinetic properties, clinical success, mechanical complications, and systemic safety.


antibiotic-loaded bone cement.; hip infection; hip spacer; knee infection; knee spacer

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Competing Interests: The author has declared that no competing interest exists.

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