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Oncol Lett. 2017 May;13(5):2949-2956. doi: 10.3892/ol.2017.5852. Epub 2017 Mar 13.

MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1.

Author information

1
Department of Gynecology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
2
Central Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

Abstract

Although microRNAs (miRNAs or miRs) are able to function as oncogenes or tumor suppressors, the role of miR-326 in regulating human cervical cancer cells remains unclear. In the present study, the expression of miR-326 was identified to be downregulated in cervical cancer cell lines and primary tumor samples, and the overexpression of miR-326 decreased cell proliferation, migration and invasion in cervical cell lines. Bioinformatics prediction and experimental validation results revealed that the function of miR-326 was achieved by targeting and repressing ETS domain-containing protein Elk-1 (ELK1) expression. ELK1 was targeted directly by miR-326, which was downregulated in human cervical cancer tissues compared with that in adjacent normal tissues. The results of the present study suggest that miR-326, a potential tumor suppressor, may be used in the treatment of cervical cancer.

KEYWORDS:

ETS domain-containing protein Elk-1; cervical cancer; microRNA-326

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