Format

Send to

Choose Destination
Ther Adv Neurol Disord. 2017 May;10(5):229-239. doi: 10.1177/1756285616682675. Epub 2017 Feb 1.

Complementary and alternative interventions for fatigue management after traumatic brain injury: a systematic review.

Author information

1
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Stomatological Hospital, Xi'an Jiaotong University and First Affiliated Hospital of Xi'an Medical University, Xi'an, China.
2
First Affiliated Hospital of Xi'an Medical University, China.
3
First Affiliated Hospital, Xi'an Jiaotong University, China.
4
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Stomatological Hospital, Xi'an Jiaotong University, 98 West 5th Road, Xi'an, Shaanxi 710004, China.

Abstract

BACKGROUND:

We systematically reviewed randomized controlled trials (RCTs) of complementary and alternative interventions for fatigue after traumatic brain injury (TBI).

METHODS:

We searched multiple online sources including ClinicalTrials.gov, the Cochrane Library database, MEDLINE, CINAHL, Embase, the Web of Science, AMED, PsychINFO, Toxline, ProQuest Digital Dissertations, PEDro, PsycBite, and the World Health Organization (WHO) trial registry, in addition to hand searching of grey literature. The methodological quality of each included study was assessed using the Jadad scale, and the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. A descriptive review was performed.

RESULTS:

Ten RCTs of interventions for post-TBI fatigue (PTBIF) that included 10 types of complementary and alternative interventions were assessed in our study. There were four types of physical interventions including aquatic physical activity, fitness-center-based exercise, Tai Chi, and aerobic training. The three types of cognitive and behavioral interventions (CBIs) were cognitive behavioral therapy (CBT), mindfulness-based stress reduction (MBSR), and computerized working-memory training. The Flexyx Neurotherapy System (FNS) and cranial electrotherapy were the two types of biofeedback therapy, and finally, one type of light therapy was included. Although the four types of intervention included aquatic physical activity, MBSR, computerized working-memory training and blue-light therapy showed unequivocally effective results, the quality of evidence was low/very low according to the GRADE system.

CONCLUSIONS:

The present systematic review of existing RCTs suggests that aquatic physical activity, MBSR, computerized working-memory training, and blue-light therapy may be beneficial treatments for PTBIF. Due to the many flaws and limitations in these studies, further controlled trials using these interventions for PTBIF are necessary.

KEYWORDS:

complementary and alternative medicine; fatigue; intervention; systematic review; traumatic brain injury

Conflict of interest statement

Conflict of interest statement: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center