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Fitoterapia. 2017 Jul;120:17-24. doi: 10.1016/j.fitote.2017.05.004. Epub 2017 May 18.

Anti-inflammatory activities of compounds from twigs of Morus alba.

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College of Pharmacy, Catholic University of Daegu, Gyeongbuk 38430, Republic of Korea.
College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address:
Korean Medicine of College, Daegu Haany University, Daegu 42158, Republic of Korea.
Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.
Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-Do 24341, Republic of Korea.
College of Pharmacy, Catholic University of Daegu, Gyeongbuk 38430, Republic of Korea. Electronic address:


Five new compounds, 10-oxomornigrol F (1), (7″R)-(-)-6-(7″-hydroxy-3″,8″-dimethyl-2″,8″-octadien-1″-yl)apigenin (2), ramumorin A (3), ramumorin B (4), and (4S,7S,8R)-trihydroxyoctadeca-5Z-enoic acid (5), together with 31 known compounds (6-36), were isolated from the twigs of Morus alba (Moraceae). The chemical structures of these compounds were established using spectroscopic analyses, 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and Mosher's methods. The anti-inflammatory activities of the compounds were evaluated by investigating their ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW 264.7 cells. Compounds 1, 2, 13, 17, 19, 25-28, and 32 showed inhibitory effects with IC50 values ranging from 2.2 to 5.3μg/mL. Compounds 1, 2, 17, 25, and 32 reduced LPS-induced inducible nitric oxide synthase (iNOS) expression in a concentration-dependent manner. In addition, pretreating the cells with compound 1, 17, and 32 significantly suppressed LPS-induced expression of cyclooxygenase-2 (COX-2) protein.


Anti-inflammatory activity; Flavonoid; Moraceae; Morus alba; NO inhibition

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