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Antiviral Res. 1988 Nov;10(1-3):1-9.

Synergy of antiviral actions of TNF and IFN-gamma: evidence for a major role of TNF-induced IFN-beta.

Author information

1
Department of Microbiology, University of Texas Medical Branch, Galveston 77550.

Abstract

Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-gamma) directly and through induction of IFN-beta in HEp-2 cells. Antibody to IFN-beta inhibits a large component of the TNF and IFN-gamma synergy and immunoreactive IFN-beta can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-beta is demonstrated.

PMID:
2852914
DOI:
10.1016/0166-3542(88)90010-1
[Indexed for MEDLINE]

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