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Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:3-12. doi: 10.1016/j.mrrev.2016.07.002. Epub 2016 Jul 5.

Human papillomavirus molecular biology.

Author information

1
Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, 02115, USA; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, 02111, USA.
2
Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, 02111, USA. Electronic address: karl.munger@tufts.edu.

Abstract

Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses.

KEYWORDS:

Cervical cancer; Epithelial differentiation; Human papillomavirus; Oncogene; Tumor suppressor; Vaccine

PMID:
28528688
PMCID:
PMC5500221
DOI:
10.1016/j.mrrev.2016.07.002
[Indexed for MEDLINE]
Free PMC Article

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