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Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:123-133. doi: 10.1016/j.mrrev.2016.08.002. Epub 2016 Aug 5.

IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome.

Author information

1
Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Israel. Electronic address: Laronz@clalit.org.il.
2
Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Israel.
3
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Abstract

Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.

PMID:
28528685
DOI:
10.1016/j.mrrev.2016.08.002
[Indexed for MEDLINE]

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