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Food Res Int. 2017 Jun;96:64-71. doi: 10.1016/j.foodres.2017.03.019. Epub 2017 Mar 11.

The hypoglycemic effects of guava leaf (Psidium guajava L.) extract are associated with improving endothelial dysfunction in mice with diet-induced obesity.

Author information

1
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avenida Fuentenueva s/n, 18071 Granada, Spain; Research and Development Centre for Functional Food (CIDAF), Health-Science Technological Park, Avenida del Conocimiento 37, 18016 Granada, Spain.
2
CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain. Electronic address: albarnogales@gmail.com.
3
CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.
4
CIBER-Enfermedades Cardiovasculares, Department of Pharmacology, ibs.GRANADA, School of Pharmacy, University of Granada, 18071 Granada, Spain.
5
Department of Chemistry and Physics (Analytical Chemistry Area) and Research Centre for Agricultural and Food Biotechnology (BITAL), Agrifood Campus of International Excellence, ceiA3, University of Almería, Carretera de Sacramento s/n, E-04120 Almería, Spain.

Abstract

Obesity is associated with a low-grade inflammatory status that affects vascular function. Previous studies have reported the beneficial effects of Psidium guajava L. (guava) on diabetes. Here we evaluate the how guava leaf extract at the dose of 5 mg/kg, affects vascular dysfunction in obese mice fed a high-fat diet for 7 weeks. Extract intake did not alter weight over time, although it reduced glycemia and insulin resistance, improving the serum lipid profile in obese mice. Additionally, guava leaf extract reversed the endothelial dysfunction found in obese mice in terms of endothelium- and NO (nitric oxide)-dependent vasodilatation induced by acetylcholine in aortic rings. In conclusion, the beneficial effects of guava leaf extract in obese mice were associated with improved vascular functions altered by obesity, probably due to its phenolic content.

KEYWORDS:

Diet-induced obesity; Endothelial dysfunction; Flavan-3-ol; Flavonol; Guava leaf extract; Mouse

PMID:
28528109
DOI:
10.1016/j.foodres.2017.03.019
[Indexed for MEDLINE]

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