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Trends Neurosci. 2017 Jun;40(6):358-370. doi: 10.1016/j.tins.2017.04.001. Epub 2017 May 17.

The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis.

Author information

1
Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
2
Biogen, Cambridge, MA, USA.
3
Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. Electronic address: richard.wade-martins@dpag.ox.ac.uk.

Abstract

Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson's disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment.

PMID:
28527591
PMCID:
PMC5462417
DOI:
10.1016/j.tins.2017.04.001
[Indexed for MEDLINE]
Free PMC Article

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