Format

Send to

Choose Destination
Mol Diagn Ther. 2017 Oct;21(5):547-554. doi: 10.1007/s40291-017-0280-1.

Association of the miR-196a2, miR-146a, and miR-499 Polymorphisms with Asthma Phenotypes in a Korean Population.

Author information

1
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.
2
Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, South Korea.
3
Clinical Trial Center, Ajou University Medical Center, Suwon, South Korea.
4
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea. kimsh@ajou.ac.kr.
5
Clinical Trial Center, Ajou University Medical Center, Suwon, South Korea. kimsh@ajou.ac.kr.

Abstract

BACKGROUND:

MicroRNAs (miRNAs) modulate expressions of inflammatory genes, thereby regulating inflammatory responses. Single nucleotide polymorphisms (SNPs) in miRNAs could affect their efficiency in binding to messenger RNAs (mRNAs).

OBJECTIVE:

We investigated the associations of miRNA SNPs with asthma phenotypes. miR-196a2 (rs11614913 T>C), miR-146a (rs2910164 C>G), and miR-499 (rs3746444 A>G) were genotyped in 347 asthma patients and 172 normal healthy controls (NCs).

RESULTS:

The CT/CC genotype of miR-196a2 rs11614913 was associated with eosinophilic asthma (p = 0.004) and a higher sputum eosinophil count compared with the TT genotype (p = 0.003). The CG/GG genotype of miR-146a rs2910164 tended to be associated with higher bronchial hyperresponsiveness to methacholine (PC20) compared with the CC genotype. The AG/GG genotype of miR-499 rs3746444 was associated with higher predicted values of forced expiratory volume in 1 s (%FEV1) compared with the AA genotype (p = 0.008).

CONCLUSIONS:

Genetic polymorphisms in miR-196a2, miR-146a, and miR-499 could be potential biomarkers for asthma phenotypes and targets for asthma treatments in a Korean population.

KEYWORDS:

Airway Hyperresponsiveness; Airway Smooth Muscle; Asthma; Chronic Obstructive Pulmonary Disease; Normal Control Group

PMID:
28527151
DOI:
10.1007/s40291-017-0280-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center