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Cell Chem Biol. 2017 May 18;24(5):548-550. doi: 10.1016/j.chembiol.2017.05.006.

"Expand and Click": A New Method for Labeling HIV-1 Envelope Glycoproteins.

Author information

1
Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.
2
Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. Electronic address: efreed@nih.gov.

Abstract

In this issue of Cell Chemical Biology, Sakin et al. (2017) investigate the nanoscale behavior of the HIV-1 envelope (Env) glycoprotein complex by using genetic code expansion, bioorthogonal amino acids, synthetic dyes, and click chemistry. This minimally invasive approach allows the measurement of native Env cellular distribution and dynamics.

PMID:
28525770
DOI:
10.1016/j.chembiol.2017.05.006
[Indexed for MEDLINE]
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