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Cell. 2017 May 18;169(5):780-791. doi: 10.1016/j.cell.2017.04.022.

Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression.

Author information

1
Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Department of Cell Biology, Erasmus University Medical Center, 3015 CE Rotterdam, the Netherlands. Electronic address: b.v.steensel@nki.nl.
2
Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: asbel@illinois.edu.

Abstract

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.

KEYWORDS:

LADs; chromosome architecture; gene repression; heterochromatin; lamina-associated domains; nuclear architecture

PMID:
28525751
PMCID:
PMC5532494
DOI:
10.1016/j.cell.2017.04.022
[Indexed for MEDLINE]
Free PMC Article

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