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ACS Nano. 2017 Jun 27;11(6):5195-5214. doi: 10.1021/acsnano.7b01493. Epub 2017 May 19.

Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation.

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Centro de Biotecnología-FEMSA, Tecnológico de Monterrey , Ave. Eugenio Garza Sada 2501, Col. Tecnológico, CP 64849 Monterrey, Nuevo León, México.
Wyss Institute for Biologically Inspired Engineering, Harvard University , Boston, Massachusetts 02115, United States.
UConn Venture Development and Incubation, UConn , Storrs, CT 06269, United States.
Division of Interventional Radiology, Mayo Clinic , Scottsdale, Arizona 85259, United States.
Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University , Wenzhou 325000, China.
Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University , Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.


We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events. In therapeutics, we describe the utilization of micro- and nanotechnologies in applications including drug delivery, tissue engineering, and pharmaceutical development/testing. In addition, we discuss relevant challenges that micro- and nanotechnologies face in achieving cost-effective and widespread clinical implementation as well as forecasted applications of micro- and nanotechnologies in medicine.


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