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Eur J Dermatol. 2017 Jun 1;27(3):260-265. doi: 10.1684/ejd.2017.3015.

High-frequency ultrasound imaging for cutaneous neurofibroma in patients with neurofibromatosis type I.

Author information

1
Department of Dermatology, CHRU, Tours, France, University François-Rabelais, Tours, France.
2
Department of Dermatology, CHRU, Tours, France.
3
Department of Dermatology, CHRU, Tours, France, INSERM U930, University François-Rabelais, Tours, France.
4
INSERM U930, University François-Rabelais, Tours, France, CIC-IT, CHRU, Tours, France.

Abstract

Neurofibromas (NFs) are benign tumours arising from a nerve sheath, which are present in nearly all patients with neurofibromatosis type 1 (NF1). High-frequency ultrasound (HFU) systems, using frequencies over 20 MHz, were developed to improve visualization of skin tumours by means of increased resolution. To describe NFs by using HFU in patients with NF1. Anonymized HFU (25-MHz) images of NFs were randomized. Initially, two dermatologist investigators, with experience in HFU imaging of the skin, together described the ultrasound images and established eight criteria for NFs. The same task was then repeated by two other dermatologists, also with experience in HFU imaging of the skin, independently, to establish inter-observer agreement. A total of 108 NFs in 29 patients were included. Superficial and subcutaneous NFs were hypoechoic with a round to spindle shape. Plexiform NFs were ill-defined, consisting of multiple hypoechoic linear zones. Good to excellent inter-observer agreement was found for six of the eight criteria (k>0.6). This is the first series describing HFU skin imaging of NFs in patients with NF1. Lateral extension that may correspond to involvement of an adjacent nerve seems to be specific to NFs.

KEYWORDS:

neurofibroma; neurofibromatosis type 1; skin; tumour; ultrasonography

PMID:
28524060
DOI:
10.1684/ejd.2017.3015
[Indexed for MEDLINE]

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