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Protein Cell. 2018 Feb;9(2):196-206. doi: 10.1007/s13238-017-0423-5. Epub 2017 May 18.

Structural and functional roles of ether lipids.

Author information

1
Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
2
Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA. ilodhi@wustl.edu.

Abstract

Ether lipids, such as plasmalogens, are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This seemingly simple biochemical change has profound structural and functional implications. Notably, the tendency of ether lipids to form non-lamellar inverted hexagonal structures in model membranes suggests that they have a role in facilitating membrane fusion processes. Ether lipids are also important for the organization and stability of lipid raft microdomains, cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential significance in human disorders, including neurological diseases, cancer, and metabolic disorders.

KEYWORDS:

cancer; ether lipids; metabolic disorders; peroxisomes; phospholipid; plasmalogen

PMID:
28523433
PMCID:
PMC5818364
DOI:
10.1007/s13238-017-0423-5
[Indexed for MEDLINE]
Free PMC Article

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