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J Menopausal Med. 2017 Apr;23(1):1-4. doi: 10.6118/jmm.2017.23.1.1. Epub 2017 Apr 28.

Cell Therapy Products in Alzheimer Disease.

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Department of Life Science and Biotechnology, Soonchunhyang University College of Natural Sciences, Asan, Korea.
Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.
Department of Urology, Soonchunhyang University College of Medicine, Bucheon, Korea.
Department of Health Administration and Management, Soonchunhyang University College of Medical Sciences, Asan, Korea.
Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Korea.
Department of Medical (CRO), The Way Communications Corporation, Seoul, Korea.
Department of Obstetrics and Gynecology, Chosun University Hospital, Gwangju, Korea.


We are rapidly becoming an aging society, with the ongoing increase in challenges of the elderly. The age-related cognitive decline in accordance with aging society is of major importance in public health. Recent studies have proved the impacts of sex-steroid hormone on the brain; compliant with aging, menopause and decrease in estrogen have an effect on the occurrence and prevention of Alzheimer's disease. A new hypothesis states that Alzheimer's disease is a postmenopausal dementia, and is a negative form of estrogen deficiency. In this review article, we reckoned the cause of postmenopausal Alzheimer's disease. We further investigated new cell therapies for postmenopausal Alzheimer's disease, which are under development in some pharmaceutical companies. One remedy is cell therapy that inhibits the amyloid beta formation, and the other is the umbilical cord blood derived mesenchymal stem cell therapy.


Alzheimer's disease; Cell- and tissue-based therapy; Menopause; Stem cells

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Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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