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Brain Behav. 2017 Apr 10;7(5):e00687. doi: 10.1002/brb3.687. eCollection 2017 May.

Strategy-based reasoning training modulates cortical thickness and resting-state functional connectivity in adults with chronic traumatic brain injury.

Author information

1
®Center for BrainHealth® School of Behavioral and Brain Sciences The University of Texas at Dallas Dallas TX USA.
2
Department of Psychiatry University of Texas Southwestern Medical Center Dallas TX USA.

Abstract

INTRODUCTION:

Prior studies have demonstrated training-induced changes in the healthy adult brain. Yet, it remains unclear how the injured brain responds to cognitive training months-to-years after injury.

METHODS:

Sixty individuals with chronic traumatic brain injury (TBI) were randomized into either strategy-based (= 31) or knowledge-based (= 29) training for 8 weeks. We measured cortical thickness and resting-state functional connectivity (rsFC) before training, immediately posttraining, and 3 months posttraining.

RESULTS:

Relative to the knowledge-based training group, the cortical thickness of the strategy-based training group showed diverse temporal patterns of changes over multiple brain regions (pvertex < .05, pcluster < .05): (1) increases followed by decreases, (2) monotonic increases, and (3) monotonic decreases. However, network-based statistics (NBS) analysis of rsFC among these regions revealed that the strategy-based training group induced only monotonic increases in connectivity, relative to the knowledge-based training group (|Z| > 1.96, pNBS < 0.05). Complementing the rsFC results, the strategy-based training group yielded monotonic improvement in scores for the trail-making test (< .05). Analyses of brain-behavior relationships revealed that improvement in trail-making scores were associated with training-induced changes in cortical thickness (pvertex < .05, pcluster < .05) and rsFC (pvertex < .05, pcluster < .005) within the strategy-based training group.

CONCLUSIONS:

These findings suggest that training-induced brain plasticity continues through chronic phases of TBI and that brain connectivity and cortical thickness may serve as markers of plasticity.

KEYWORDS:

functional connectivity; magnetic resonance imaging; morphometry; plasticity; rehabilitation; traumatic brain injury

PMID:
28523229
PMCID:
PMC5434192
DOI:
10.1002/brb3.687
[Indexed for MEDLINE]
Free PMC Article

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