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Clin Transl Immunology. 2017 Apr 7;6(4):e136. doi: 10.1038/cti.2017.9. eCollection 2017 Apr.

Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions.

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Department of Immunology, Virology and Inflammation, Cancer Research Center of Lyon UMR INSERM1052, CNRS 5286, Centre Léon Bérard Hospital, Université de Lyon, Equipe labellisée LIGUE, Lyon, France.
TGF-β and Immuno-evasion Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.


The relationship between host organisms and their microbiota has co-evolved towards an inter-dependent network of mutualistic interactions. This interplay is particularly well studied in the gastrointestinal tract, where microbiota and host immune cells can modulate each other directly, as well as indirectly, through the production and release of chemical molecules and signals. In this review, we define the functional impact of transforming growth factor-beta (TGF-β) on this complex interplay, especially through its modulation of the activity of local regulatory T cells (Tregs), type 17 helper (Th17) cells, innate lymphoid cells (ILCs) and B cells.

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The authors declare no conflict of interest.

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