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ACS Med Chem Lett. 2017 Apr 18;8(5):476-480. doi: 10.1021/acsmedchemlett.7b00114. eCollection 2017 May 11.

Biocatalysis in the Pharmaceutical Industry: The Need for Speed.

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Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States.


The use of biocatalysis in the pharmaceutical industry continues to expand as a result of increased access to enzymes and the ability to engineer those enzymes to meet the demands of industrial processes. However, we are still just scratching the surface of potential biocatalytic applications. The time pressures present in pharmaceutical process development are incompatible with the long lead times required for engineering a suitable biocatalyst. Dramatic increases in the speed of protein engineering are needed to deliver on the ever increasing opportunities for industrial biocatalytic processes.


Biocatalysis; enzymes; protein engineering; sustainability

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