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Trends Biochem Sci. 2017 Jun;42(6):412-413. doi: 10.1016/j.tibs.2017.04.008. Epub 2017 May 15.

Inhibiting Translation One Protein at a Time.

Author information

1
Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458. Electronic address: Disney@scripps.edu.

Abstract

Historically, translational inhibitors have been confined to anti-bacterials that globally affect translation. Lintner et al. demonstrate that small molecules can specifically inhibit translation of a single disease-associated protein by stalling the ribosome's nascent chain [1], opening up a new therapeutic strategy for 'undruggable' proteins.

PMID:
28522328
DOI:
10.1016/j.tibs.2017.04.008
[Indexed for MEDLINE]

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