Format

Send to

Choose Destination
Cancer Radiother. 2017 Jun;21(4):286-290. doi: 10.1016/j.canrad.2017.01.015. Epub 2017 May 15.

A large French multicenter retrospective series of T1-T2N0 vocal cords carcinomas treated with exclusive irradiation.

Author information

1
Department of Oncology Radiotherapy, pôle Henry-S-Kaplan, CHRU Bretonneau, 2, boulevard Tonnellé, 37044 Tours, France. Electronic address: rob.aurel@gmail.com.
2
Department of Oncology Radiotherapy, centre Jean-Bernard-clinique Victor-Hugo, 9, rue Beauverger, 72000 Le Mans, France.
3
Department of Oncology Radiotherapy, pôle Henry-S-Kaplan, CHRU Bretonneau, 2, boulevard Tonnellé, 37044 Tours, France.
4
Department of Oncology Radiotherapy, centre René-Gauducheau, institut de cancérologie de l'Ouest, boulevard Professeur-Jacques-Monod, 44805 Saint-Herblain, France.
5
Department of Oncology Radiotherapy, centre hospitalier régional d'Orléans, 14, avenue de l'Hôpital, 45100 Orléans, France.
6
Groupe oncologie radiothérapie tête et cou (GORTEC), association Gortec, Corad Chu Bretonneau, 37044 Tours cedex 1, France.

Abstract

PURPOSE:

The main objective of this study was to evaluate the 5-year efficacy of exclusive laryngeal radiotherapy without node prophylactic irradiation for localized cancers of the vocal cords.

PATIENTS AND METHODS:

We retrospectively reviewed charts from 258 patients with T1-T2N0 glottic carcinoma irradiated from April 1987 to March 2015 in four France western centers, including pretreated patients. Toxicity was analyzed according to CTCAE v4.0 classification.

RESULTS:

The median follow-up was 50 months. The median age was 67 years with 87% men and 85.5% had T1 tumor. Five years overall survival was 77.5% (95% confidence interval [95% CI]: 71.4-83.5), 5 years local control was 86.8% (95% CI: 82.3-91.3), specific survival rate was 95% (95% CI: 92.2-97.9) and final laryngectomy-free survival was 87.5% (95% CI: 82.2-92.9). Most toxicities were grade 1 and 2. Grade 3 acute toxicity was 15.5% for the radiation laryngitis, 3.5% for radiodermatitis and 7.7% for dysphonia. Grade 3 chronic toxicity was 3.5% for dysphonia and there were two cases of tracheal stenosis treated by tracheotomy.

CONCLUSION:

Radiotherapy provides good results in local control of stage I and II vocal cords cancers as well as the toxicity level.

KEYWORDS:

Cancer glottique; Cordes vocales; Glottic cancer; Localized radiotherapy; Radiothérapie localisée; T1-T2N0; Vocal cord

PMID:
28522278
DOI:
10.1016/j.canrad.2017.01.015
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center