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Cell Calcium. 2018 Mar;70:56-63. doi: 10.1016/j.ceca.2017.05.004. Epub 2017 May 10.

Calcium and regulation of the mitochondrial permeability transition.

Author information

1
Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy.
2
Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy. Electronic address: bernardi@bio.unipd.it.

Abstract

Recent years have seen renewed interest in the permeability transition pore, a high conductance channel responsible for permeabilization of the inner mitochondrial membrane, a process that leads to depolarization and Ca2+ release. Transient openings may be involved in physiological Ca2+ homeostasis while long-lasting openings may trigger and/or execute cell death. In this review we specifically focus (i) on the hypothesis that the PTP forms from the F-ATP synthase and (ii) on the mechanisms through which Ca2+ can reversibly switch this energy-conserving nanomachine into an energy-dissipating device.

KEYWORDS:

Ca(2+); Channels; F-ATP synthase; Mitochondria; Permeability transition

PMID:
28522037
DOI:
10.1016/j.ceca.2017.05.004
[Indexed for MEDLINE]

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