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Metabolism. 2017 Jun;71:144-152. doi: 10.1016/j.metabol.2017.03.001. Epub 2017 Mar 8.

Effect of a single bout of aerobic exercise on high-fat meal-induced inflammation.

Author information

1
The Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA; Department of Kinesiology, Iowa State University, Ames, IA.
2
Department of Kinesiology, Iowa State University, Ames, IA; The Immunobiology Interdepartmental Graduate Program, Iowa State University, Ames, IA.
3
Department of Kinesiology, Iowa State University, Ames, IA. Electronic address: rvalenti@iastate.edu.

Abstract

BACKGROUND AND AIMS:

Chronic low-grade inflammation is involved in the development of metabolic disorders including atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Aerobic exercise has been shown to be anti-inflammatory and attenuate postprandial blood lipids, however, the effect of exercise on postprandial inflammation remains unclear. The aim of this study was to determine the protective effect of a single bout of aerobic exercise against postprandial lipemia and peripheral blood mononuclear cell (PBMC) inflammation and to evaluate associations with changes in the energy-sensing enzyme, AMP-activated protein kinase (AMPK).

MATERIALS AND METHODS:

Healthy male subjects (n=12, age=23±2, %Fat=19±2) reported to the laboratory following an overnight fast (12-14h) on two separate occasions for consumption of a high-fat meal (HFM). Participants completed an acute bout of aerobic exercise the afternoon prior to one of the HFM visits.

RESULTS AND CONCLUSION:

Results indicate that the single bout of moderate aerobic exercise increased AMPK signaling in PBMCs, as shown by increased phosphorylated acetyl-CoA carboxylase (p-ACC). This may be due to decreases in the AMPK inhibitory kinases PKD and GSK3β. Additionally, prior moderate intensity exercise decreased postprandial lipemia (PPL) and some mediators of the inflammatory pathway, such as p-NF-κB. These findings that acute aerobic exercise improves AMPK and NF-κB signaling in human PBMCs contribute support to the anti-inflammatory roles of exercise.

KEYWORDS:

AMP-activated protein kinase; Nuclear factor-κB; Peripheral blood mononuclear cells; Postprandial lipemia

PMID:
28521867
DOI:
10.1016/j.metabol.2017.03.001
[Indexed for MEDLINE]

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