Send to

Choose Destination
Schizophr Bull. 2018 Feb 15;44(2):443-452. doi: 10.1093/schbul/sbx068.

Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia.

Author information

The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM.
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Department of Neurosciences, University of New Mexico, Albuquerque, NM.
Department of Psychiatry, University of New Mexico, Albuquerque, NM.
Department of Psychology, Georgia State University, Atlanta, GA.
Department of Psychology, University of New Mexico, Albuquerque, NM.
Department of Biomedical Engineering, Tulane University, New Orleans, LA.
Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
School of Computer and Information Technology, Shanxi University, Taiyuan, China.
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA.
Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Department of Electronic and Computer Engineering, University of New Mexico, Albuquerque, NM.


Closely linking genetics and environment factors, epigenetics has been of increasing interest in psychiatric disease studies. In this work, we integrated single nucleotide polymorphisms (SNPs), DNA methylation of blood and saliva, and brain gray matter (GM) measures to explore the role of genetic and epigenetic variation to the brain structure changes in schizophrenia (SZ). By focusing on the reported SZ genetic risk regions, we applied a multi-stage multivariate analysis to a discovery dataset (92 SZ patients and 110 controls, blood) and an independent replication dataset (93 SZ patients and 99 controls, saliva). Two pairs of SNP-methylation components were significantly correlated (r = .48 and .35) in blood DNA, and replicated (r = .46 and .29) in saliva DNA, reflecting cross-tissue SNP cis-effects. In the discovery data, both SNP-related methylation components were also associated with one GM component primarily located in cerebellum, caudate, and thalamus. Additionally, another methylation component in NOSIP gene with significant SZ patient differences (P = .009), was associated with 8 GM components (7 with patient differences) including superior, middle, and inferior frontal gyri, superior, middle, and inferior temporal gyri, cerebellum, insula, cuneus, and lingual gyrus. Of these, 5 methylation-GM associations were replicated (P < .05). In contrast, no pairwise significant associations were observed between SNP and GM components. This study strongly supports that compared to genetic variation, epigenetics show broader and more significant associations with brain structure as well as diagnosis, which can be cross-tissue, and the potential in explaining the mechanism of genetic risks in SZ.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center