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Cereb Cortex. 2018 Jul 1;28(7):2207-2232. doi: 10.1093/cercor/bhx121.

Computing the Social Brain Connectome Across Systems and States.

Author information

1
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany.
2
Department of Psychology, York Neuroimaging Centre, University of York, Hesslington, York, UK.
3
Department of Psychology, Vrije Universiteit Brussel, Brussels, Belgium.
4
Department of Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany.
5
Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
6
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EZ Nijmegen, The Netherlands.
7
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
8
Department of Physics, Florida International University, Miami, FL, USA.
9
Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA.
10
Medical Faculty, Institute for Systems Neuroscience, Heinrich-Heine University, Düsseldorf, Germany.
11
Institute for Neuroscience and Medicine (INM-7, Brain & Behavior), Research Center Jülich, Jülich, Germany.
12
Parietal Team, INRIA, Neurospin, bat 145, CEA Saclay, Gif-sur-Yvette, France.
13
JARA, Translational Brain Medicine, Aachen, Germany.

Abstract

Social skills probably emerge from the interaction between different neural processing levels. However, social neuroscience is fragmented into highly specialized, rarely cross-referenced topics. The present study attempts a systematic reconciliation by deriving a social brain definition from neural activity meta-analyses on social-cognitive capacities. The social brain was characterized by meta-analytic connectivity modeling evaluating coactivation in task-focused brain states and physiological fluctuations evaluating correlations in task-free brain states. Network clustering proposed a functional segregation into (1) lower sensory, (2) limbic, (3) intermediate, and (4) high associative neural circuits that together mediate various social phenomena. Functional profiling suggested that no brain region or network is exclusively devoted to social processes. Finally, nodes of the putative mirror-neuron system were coherently cross-connected during tasks and more tightly coupled to embodied simulation systems rather than abstract emulation systems. These first steps may help reintegrate the specialized research agendas in the social and affective sciences.

PMID:
28521007
DOI:
10.1093/cercor/bhx121

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