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Clin Endosc. 2017 Jul;50(4):357-365. doi: 10.5946/ce.2016.152. Epub 2017 May 16.

Necrotizing Pancreatitis: Current Management and Therapies.

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Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO, USA.
Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.


Acute necrotizing pancreatitis accounts for 10% of acute pancreatitis (AP) cases and is associated with a higher mortality and morbidity. Necrosis within the first 4 weeks of disease onset is defined as an acute necrotic collection (ANC), while walled off pancreatic necrosis (WOPN) develops after 4 weeks of disease onset. An infected or symptomatic WOPN requires drainage. The management of pancreatic necrosis has shifted away from open necrosectomy, as it is associated with a high morbidity, to less invasive techniques. In this review, we summarize the current management and therapies for acute necrotizing pancreatitis.


Necrosis; Pancreatitis; Pseudocyst; Walled-off pancreatic necrosis

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