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Clin Endosc. 2017 Jul;50(4):357-365. doi: 10.5946/ce.2016.152. Epub 2017 May 16.

Necrotizing Pancreatitis: Current Management and Therapies.

Author information

1
Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO, USA.
2
Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Abstract

Acute necrotizing pancreatitis accounts for 10% of acute pancreatitis (AP) cases and is associated with a higher mortality and morbidity. Necrosis within the first 4 weeks of disease onset is defined as an acute necrotic collection (ANC), while walled off pancreatic necrosis (WOPN) develops after 4 weeks of disease onset. An infected or symptomatic WOPN requires drainage. The management of pancreatic necrosis has shifted away from open necrosectomy, as it is associated with a high morbidity, to less invasive techniques. In this review, we summarize the current management and therapies for acute necrotizing pancreatitis.

KEYWORDS:

Necrosis; Pancreatitis; Pseudocyst; Walled-off pancreatic necrosis

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