Send to

Choose Destination
Indian J Psychol Med. 2017 Mar-Apr;39(2):209-212. doi: 10.4103/0253-7176.203130.

Delayed Stevens-Johnson Syndrome Secondary to the Use of Lamotrigine in Bipolar Mood Disorder.

Author information

Department of Critical Care Medicine, Geisinger Medical Center, Danville, PA 17821, USA.
Department of Internal Medicine, Norvic International Hospital, Kathmandu, Nepal.
Dental Surgeon, Oracare Periodontal Clinic, Kathamandu, Nepal.
Department of Internal Medicine Possible Health, Achham, Nepal.


Lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar I disease. There are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis. SJS is a life-threatening, blistering mucocutaneous disease. SJS is characterized by the presence of flat, diffuse erythematous maculopapular rashes with the involvement of <10% of the body surface area. Standard trigger is drugs including anticonvulsants, antibiotics, and Mycoplasma pneumoniae infection. We report a case where a patient developed SJS secondary to delayed-type hypersensitivity reaction after 6 months of the use of lamotrigine, while his initial response during the first 6 months did not show any sign of SJS.


Bipolar mood disorder; Steven–Johnson syndrome; delayed skin reactions; lamotrigine

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center