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Indian J Psychol Med. 2017 Mar-Apr;39(2):209-212. doi: 10.4103/0253-7176.203130.

Delayed Stevens-Johnson Syndrome Secondary to the Use of Lamotrigine in Bipolar Mood Disorder.

Author information

1
Department of Critical Care Medicine, Geisinger Medical Center, Danville, PA 17821, USA.
2
Department of Internal Medicine, Norvic International Hospital, Kathmandu, Nepal.
3
Dental Surgeon, Oracare Periodontal Clinic, Kathamandu, Nepal.
4
Department of Internal Medicine Possible Health, Achham, Nepal.

Abstract

Lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar I disease. There are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis. SJS is a life-threatening, blistering mucocutaneous disease. SJS is characterized by the presence of flat, diffuse erythematous maculopapular rashes with the involvement of <10% of the body surface area. Standard trigger is drugs including anticonvulsants, antibiotics, and Mycoplasma pneumoniae infection. We report a case where a patient developed SJS secondary to delayed-type hypersensitivity reaction after 6 months of the use of lamotrigine, while his initial response during the first 6 months did not show any sign of SJS.

KEYWORDS:

Bipolar mood disorder; Steven–Johnson syndrome; delayed skin reactions; lamotrigine

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