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Am J Chin Med. 2017;45(4):813-832. doi: 10.1142/S0192415X17500434. Epub 2017 May 18.

The Effects of Gymnema sylvestre in High-Fat Diet-Induced Metabolic Disorders.

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* College of Veterinary Medicine, Seoul National University, Gwanak-ro 1-gil, Gwanak-gu, Seoul 08826, Republic of Korea.
† Graduate Group of Tumor Biology, Seoul National University, Daehangno 103-gil, Jongno-gu, Seoul 03080, Republic of Korea.
‡ New Drug Development Center, Daegu-Gyeongbuk, Medical Innovation Foundation, 88-gil, Dong-gu, Daegu 41061, Republic of Korea.
§ R&D Center, Biterials Co., Ltd., Siksa-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea.


This study used an integrated approach to investigate the effects of Gymnema sylvestre (GS) extract as a functional dietary supplement with a high-fat diet. This approach examined insulin resistance, the dysfunction of adipose tissue, and liver steatosis. Male C57BL/6J mice were fed a normal chow or high-fat diet (HFD) for the acute and chronic study, in addition to GS in different doses (100, 250 and 500[Formula: see text]mg/kg body weight). Their body composition changes, serum lipid and glucose parameters, adipose and liver tissue histology, and gene expression were measured. It was found that GS significantly suppressed the increase of body weight, serum levels of lipid, insulin and leptin, and adipose tissue, and liver inflammation. GS also demonstrated hypoglycemic effects due to the amylase inhibition activity. Our results support the existence of a relationship between the HFD induced insulin resistance, adipose dysfunction and liver steatosis. In conclusion, GS works as a functional dietary supplement with preventative effects against metabolic disorder.


Adiposity; Diabetes; High-fat Diet; Hyperglycemia; Obesity

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