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Food Funct. 2017 Jun 1;8(6):2110-2114. doi: 10.1039/c7fo00309a. Epub 2017 May 17.

l-Ornithine stimulates growth hormone release in a manner dependent on the ghrelin system.

Author information

1
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan. ohinata@kais.kyoto-u.ac.jp.
2
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan. ohinata@kais.kyoto-u.ac.jp and Research Unit for Physiological Chemistry, C-PIER, Kyoto University, Kyoto 606-8501, Japan.
3
Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Noji-kita, Kusatsu, Shiga 525-8577, Japan and Department of Physiology II Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan.
4
Healthcare Products Development Center, Kyowa Hakko Bio Co., Ltd, Tsukuba, Ibaraki 305-0841, Japan.

Abstract

We found that intraduodenal administration of l-ornithine (l-Orn) stimulates growth hormone (GH) secretion in Wistar rats, and then investigated its mechanism. GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys3]-GHRP-6, an antagonist of the ghrelin receptor; however, l-Orn (100 μM) has no affinity for the ghrelin receptor, suggesting that the GH-releasing activity of l-Orn is mediated via ghrelin release and activation of the ghrelin receptor. Intraduodenally administered l-Orn increased ghrelin mRNA expression in the duodenum but not in the stomach or hypothalamus. In addition, l-Orn-induced GH-releasing activity was inhibited by propranolol, an antagonist of β-adrenergic receptor, which is known to be coupled to ghrelin release. In conclusion, intraduodenally administered l-Orn stimulates GH secretion through the sympathetic nervous and ghrelin systems.

PMID:
28513740
DOI:
10.1039/c7fo00309a
[Indexed for MEDLINE]

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