Format

Send to

Choose Destination
Nat Commun. 2017 May 17;8:15404. doi: 10.1038/ncomms15404.

Decoding material-specific memory reprocessing during sleep in humans.

Author information

1
Medical Psychology and Behavioral Neurobiology, Eberhard Karls Universität Tübingen, Silcherstr. 5, Tübingen 72076, Germany.
2
Bernstein Center for Computational Neuroscience, LMU München, Großhadernerstr. 2, Planegg-Martinsried 82152, Germany.
3
Department of Psychology, LMU München, Leopoldstr. 13, München 80802, Germany.

Abstract

Neuronal learning activity is reactivated during sleep but the dynamics of this reactivation in humans are still poorly understood. Here we use multivariate pattern classification to decode electrical brain activity during sleep and determine what type of images participants had viewed in a preceding learning session. We find significant patterns of learning-related processing during rapid eye movement (REM) and non-REM (NREM) sleep, which are generalizable across subjects. This processing occurs in a cyclic fashion during time windows congruous to critical periods of synaptic plasticity. Its spatial distribution over the scalp and relevant frequencies differ between NREM and REM sleep. Moreover, only the strength of reprocessing in slow-wave sleep influenced later memory performance, speaking for at least two distinct underlying mechanisms between these states. We thus show that memory reprocessing occurs in both NREM and REM sleep in humans and that it pertains to different aspects of the consolidation process.

PMID:
28513589
PMCID:
PMC5442370
DOI:
10.1038/ncomms15404
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center