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J Clin Diagn Res. 2017 Mar;11(3):OC13-OC16. doi: 10.7860/JCDR/2017/20628.9449. Epub 2017 Mar 1.

Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Trial.

Author information

1
Resident Physician, Department of Internal Medicine, Saint Peter's University Hospital, New Brunswick, New Jersey, USA.
2
Epidemiology-Biostatistics, MPH, City University of New York, New York, USA.
3
Research Associate, Department of Pulmonology, New York Methodist Hospital, New York, USA.
4
Medical Advisor Gufic Biosciences, Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India.
5
Medical Officer, Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India.

Abstract

INTRODUCTION:

Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipimea, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level.

AIM:

To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients.

MATERIALS AND METHODS:

This study was prospective, single blind, randomized comparative trial. Hundred patients were randomized into three groups. Group I received metformin 500 mg twice daily and placebo, Group II received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) once daily and the Group III received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) twice daily. ANOVA test was applied for analysis.

RESULTS:

Group II was effective in reducing the triglyceride level from 144.59±14.18 mg/dl to 101±13.31 mg/dl which was significant as compared to Group I from 147.67±18.57 mg/dl to 145.8±19.86 mg/dl respectively. Group III containing 1 g of omega-3 fatty acids twice daily showed decrease from 144.83±22.17 mg/dl to 86±17.46 mg/dl and was more effective in reducing triglyceride levels than Group II containing 1 gram of omega-3 fatty acids once daily.

CONCLUSION:

Omega-3 fatty acids can be given in conjunction with metformin to reduce triglyceride levels in diabetic dyslipidaemia without any adverse drug reactions or any drug interaction. Omega-3 fatty acids were effective in reducing the triglyceride level significantly as compared to placebo. Two grams of omega-3 fatty acids were more effective than 1 gram of omega-3 fatty acids in reducing triglyceride levels.

KEYWORDS:

Hypertriglyceridaemia; Postprandial lipimea; Triglyceride

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