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Curr Opin Virol. 2017 Jun;24:79-86. doi: 10.1016/j.coviro.2017.04.007. Epub 2017 May 13.

Functional RNA structures throughout the Hepatitis C Virus genome.

Author information

1
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
2
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA; Department of Chemistry, Yale University, New Haven, CT 06511, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: anna.pyle@yale.edu.

Abstract

The single-stranded Hepatitis C Virus (HCV) genome adopts a set of elaborate RNA structures that are involved in every stage of the viral lifecycle. Recent advances in chemical probing, sequencing, and structural biology have facilitated analysis of RNA folding on a genome-wide scale, revealing novel structures and networks of interactions. These studies have underscored the active role played by RNA in every function of HCV and they open the door to new types of RNA-targeted therapeutics.

PMID:
28511116
PMCID:
PMC5529263
DOI:
10.1016/j.coviro.2017.04.007
[Indexed for MEDLINE]
Free PMC Article

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