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Elife. 2017 May 16;6. pii: e23130. doi: 10.7554/eLife.23130.

Identification of octopaminergic neurons that modulate sleep suppression by male sex drive.

Author information

1
Department of Neuroscience, the Farber Institute for Neurosciences, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, United States.
2
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
3
ICVS/3B's - PT Government Associate Laboratory, Braga, Portugal.
4
Departments of Psychiatry and Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.

Abstract

Molecular and circuit mechanisms for balancing competing drives are not well understood. While circadian and homeostatic mechanisms generally ensure sufficient sleep at night, other pressing needs can overcome sleep drive. Here, we demonstrate that the balance between sleep and sex drives determines whether male flies sleep or court, and identify a subset of octopaminergic neurons (MS1) that regulate sleep specifically in males. When MS1 neurons are activated, isolated males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is attenuated and mating behavior is impaired. MS1 neurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calcium imaging experiments reveal bidirectional functional connectivity between MS1 and FRU neurons. We propose octopaminergic MS1 neurons interact with the FRU network to mediate sleep suppression by male sex drive.

KEYWORDS:

D. melanogaster; courtship; motivation; neuroscience; octopamine; sex; sleep

PMID:
28510528
PMCID:
PMC5433852
DOI:
10.7554/eLife.23130
[Indexed for MEDLINE]
Free PMC Article

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