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Biophys Rev. 2013 Mar;5(1):29-39. doi: 10.1007/s12551-012-0081-z. Epub 2012 Jun 20.

SH3 domains: modules of protein-protein interactions.

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Department of Biophysics, The School of Theoretical Modeling, PO Box 15676, Chevy Chase, MD, 20825, USA.
Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm 13 N240-C 10, Center Drive, Bethesda, MD, 20892, USA.


Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements in deciphering structural determinants of SH3 function.


Cell signaling; Myosin; Protein conformation; SH3 domain; Src-family; Three-dimensional structure

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