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Transpl Infect Dis. 2017 Aug;19(4). doi: 10.1111/tid.12725. Epub 2017 Jun 26.

Malignancies in hepatitis C virus-positive and -negative kidney transplant recipients: A case-controlled study.

Author information

1
Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
2
INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France.
3
Université Paul Sabatier, Toulouse, France.
4
Laboratory of Virology, CHU Purpan, Toulouse, France.

Abstract

BACKGROUND:

Malignancies and lymphoma are common complications after kidney transplantation. However, no link has been made between the incidence of malignancies and hepatitis C virus (HCV) infection in this setting. This case-controlled study compared the incidence of malignancies, including lymphoma, between kidney transplant (KT) patients with or without HCV replication.

PATIENTS AND METHODS:

A total of 99 HCV-positive RNA-positive KT patients were matched with 198 (1:2) anti-HCV-negative patients according to age, gender, and date of transplantation, and were followed for 145.8±78.4 months.

RESULTS:

During the follow-up period, 28 HCV-positive (28%) cases developed at least one cancer, and 64 (32%) patients developed cancer in the HCV-negative group (P=not significant [ns]). Survival without a cancer was similar between both groups. Thirteen HCV-positive patients (13%) developed at least one solid cancer vs 29 (15%) HCV-negative patients (P=ns). Survival without a solid cancer was similar between both groups. Three patients from the HCV-positive and 4 from the HCV-negative group developed a lymphoma. Only 2 patients from the HCV group died from hepatocellular carcinoma. Survival without a skin cancer was similar between both groups. Patient and death-censored graft survival rates were significantly lower in the HCV group.

CONCLUSION:

The incidences and types of malignancies were similar in the HCV-positive and HCV-negative KT patients.

KEYWORDS:

cancer; hepatitis C virus; kidney transplantation; lymphoma; survival

PMID:
28509330
DOI:
10.1111/tid.12725
[Indexed for MEDLINE]

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