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Infection. 2017 Oct;45(5):705-707. doi: 10.1007/s15010-017-1027-y. Epub 2017 May 15.

Surgical excision for recurrent herpes simplex virus 2 (HSV-2) anogenital infection in a patient with human immunodeficiency virus (HIV).

Author information

1
Division of Infectious Diseases, Vanderbilt University Medical Center, A2200 MCN 1161 21st Avenue South Nashville, Nashville, TN, 37232-2605, USA. folasade.a.arinze@vanderbilt.edu.
2
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
3
Division of Infectious Diseases, Vanderbilt University Medical Center, A2200 MCN 1161 21st Avenue South Nashville, Nashville, TN, 37232-2605, USA.

Abstract

Recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (HIV), of whom approximately 5% develop resistance to acyclovir. We present a case of a 49-year-old man with HIV who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. He initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. The lesion progressed to a large hypertrophic mass that required surgical excision, which led to resolution without recurrences. Our case highlights the importance of surgical excision as a treatment option in refractory herpes simplex virus anogenital infections.

KEYWORDS:

HSV-1; HSV-2; Herpes simplex infection; Hypertrophic HSV herpes simplex vegetans; Recurrent herpes simplex infection

PMID:
28508238
DOI:
10.1007/s15010-017-1027-y
[Indexed for MEDLINE]

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