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EXCLI J. 2017 Mar 14;16:265-277. doi: 10.17179/excli2017-119. eCollection 2017.

Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats.

Author information

1
Department of Biochemistry, Dongeui University College of Korean Medicine, Busan 614-052, Republic of Korea.
2
Anti-Aging Research Center, Dongeui University, Busan 614-714, Republic of Korea.
3
Department of Anatomy, Kosin University College of Medicine, Busan 602-702, Republic of Korea.
4
Department of Orthopaedic Surgery, College of Medicine, Inje University, Busan, 47392, Republic of Korea.
5
Department of Microbiology, College of Medicine, Inje University, Busan, 47392, Republic of Korea.
6
Department of Anatomy, Dongeui University College of Korean Medicine, Busan 614-052, Republic of Korea.
7
Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju, 690-756, Republic of Korea.
8
Research Institute, Bio-Port Korea INC, MarineBio-industry Development Center, Busan 619-912, Republic of Korea.
9
Department of Horticultural Bioscience, College of Natural Resource and Life Sciences, Pusan National University, Miryang 627-706, Republic of Korea.
10
Department of Molecular Biology, College of Natural Sciences and Human Ecology, Dongeui University, Busan 614-714, Republic of Korea.

Abstract

Schisandrae Fructus, the fruit of Schisandra chinensis (Turcz.) Baill., is widely used in traditional medicine for the treatment of a number of chronic diseases. Although, Schisandrae Fructus was recently reported to attenuate the interleukin (IL)-1β-induced inflammatory response in chondrocytes in vitro, its protective and therapeutic potential against osteoarthritis (OA) in an animal model remains unclear. Therefore, we investigated the effects of the ethanol extract of Schisandrae Fructus (SF) on inflammatory responses and cartilage degradation in a monosodium iodoacetate (MIA)-induced OA rat model. Our results demonstrated that administration with SF had a tendency to attenuate MIA-induced damage of articular cartilage as determined by a histological grade of OA. SF significantly suppressed the production of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in MIA-induced OA rats. SF also effectively inhibited expression of inducible nitric oxide (NO) synthase and cyclooxygenase-2, thereby inhibiting the release of NO and prostaglandin E2. In addition, the elevated levels of matrix metalloproteinases-13 and two biomarkers for diagnosis and progression of OA, such as cartilage oligomeric matrix protein and C-telopeptide of type II collagen, were markedly ameliorated by SF administration. These findings indicate that SF could be a potential candidate for the treatment of OA.

KEYWORDS:

MIA; Schisandrae Fructus; cartilage degradation; inflammatory responses; osteoarthritis

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