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Diabetes. 2017 May;66(5):1103-1110. doi: 10.2337/db16-1477.

Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer.

Author information

Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Division of Endocrinology, Department of Medicine, and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, and Indiana University Melvin and Bren Simon Cancer Center and Pancreatic Cancer Signature Center, Indianapolis, IN.
Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX.
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN.
Division of Medical Oncology, Department of Medicine, Duke University School of Medicine, Durham, NC


The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest to the oncology community as the differentiation of new-onset diabetes caused by PDAC as distinct from T2DM may allow for earlier diagnosis of PDAC. To address these relationships and raise awareness of the relationships between PDAC and diabetes, a symposium entitled Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer was held at the American Diabetes Association's 76th Scientific Sessions in June 2016. This article summarizes the data presented at that symposium, describing the current understanding of the interrelationships between diabetes, diabetes management, and pancreatic cancer, and identifies areas where additional research is needed.

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