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Diabetes. 2017 May 15. pii: db161213. doi: 10.2337/db16-1213. [Epub ahead of print]

Pair-Feeding, but not Insulin, Phloridzin, or Rosiglitazone Treatment Curtails Markers of Beta-cell Dedifferentiation in db/db Mice.

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Department of Medicine and Berrie Diabetes Center, Columbia University.
Department of Medicine and Berrie Diabetes Center, Columbia University


Beta cell failure is a hallmark of type 2 diabetes. Among several cellular biological mechanisms of cellular dysfunction, we and others have recently proposed that dedifferentiation of beta cells can explain the slowly progressive onset and partial reversibility of beta-cell failure. Accordingly, we provided evidence of such processes in humans and experimental animal models of insulin-resistant diabetes. In this study, we asked whether beta cell dedifferentiation can be prevented with diet or pharmacological treatment of diabetes. Db/db mice, a widely used model of insulin-resistant diabetes and obesity, were either pair-fed or treated with the Sglt inhibitor phloridzin, the insulin-sensitizer rosiglitazone, or insulin. All treatments were equally efficacious in reducing plasma glucose levels. Pair-feeding and phloridzin also resulted in significant weight loss. However, pair-feeding among the four treatments resulted in a reduction of beta cell dedifferentiation, as assessed by Foxo1 and Aldh1a3 immunohistochemistry. The effect of diet to partly restore beta cell function is consistent with data in human diabetes, and provides another potential mechanism by which lifestyle changes act as an effective intervention against diabetes progression.

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